In their November 2005 article Environmentally Controlled Invasion of Cancer Cells by Engineered Bacteria, SynBERC researhers Chris Anderson, Adam Arkin, and Chris Voigt describe a method for engineering the interaction between bacteria and cancer cells to depend on heterologous environmental signals. The authors point how how the approach could be used to engineer bacteria to sense the microenvironment of a tumor and respond by invading cancerous cells and releasing a cytotoxic agent (see SynBERC's Tumor-Killing Bacterium Testbed for more info). The article was one of the 10 Top Downloaded articles in Journal of Molecular Biology for 2006, suggesting enormous interest and value to researchers in the field of synthetic biology.